Dr. Ohidul Siddiqui

Professor

Office: Room 201
Phone:
Email: siddiquio@isrt.ac.bd

 

Education

Ph.D in Biostatistics, University of Illinois at Chicago. Chicago, Illinois

M.A. in Applied Statistics, Dept. of Statistics, The Ohio State University, Columbus, Ohio

M.S in Statistics, Jahangirnagar University, Banglade

B,S in Statistics, Jahangirnagar University, Bangladesh

Research Interests

Missing data in clinical trial studies, develop statistical methodologies for analyzing clinical, pre-clinical, disease modeling, and safety data.

Professional Experience 

Professor, Institute of Statistical Research and Training, Dhaka University, March 2014 – present 

Expert Mathematical Statistician (GS-15 –the highest salary grade for US Federal employees), Expert track), Division of Biometrics 1, Center for Drug Evaluation and Research (CDER), US Food and Drug Administration (FDA), March 2008 –March 2014 

Adjunct Faculty, University of Phoenix, Phoenix, June 2009 – present

Senior Mathematical Statistician (GS-14), Division of Biometrics 1, CDER, July 2002 –Feb 2008 

Mathematical Statistician (GS-13), Division of Biometrics 1, CDER, May 1999 –June 2002

Assistant Professor, Clinical Economics Research Unit, Georgetown University Medical Center, Washington, DC 20007, Aug. 1998 – May 1999. 

Lead Biostatistician, Otsuka America Pharmaceutical, Inc., 2440 Research Boulevard, Rockville, MD 20850, Sept. 1996 – Aug. 1998

Biostatistician, Prevention Research Center, School of Public Health, University of Illinois at Chicago, 850 West Jackson Bld., Suite 400, Chicago, IL 60607,  Sept. 1990 – Sept. 1996 

Statistical Consultant, Instruction and Research Computer Center, The Ohio State University, Columbus, OH  43210. Sept. 1989 – Sept. 1990 

Assistant Professor, Department of Statistics, Jahangirnagar University, Bangladesh, Jun. 1985- Aug 1989

Lecturer, Department of Statistics, Jahangirnagar University, Bangladesh, Jan. 1982- Jun 1985

Lecturer, Department of Statistics, Chittagong University, Bangladesh, Aug. 1980-Dec 1981

Publications

Haider, Z., Hossain, T., Siddiqui, O., Islam, S. Economic valuation of the tourist spots in Bangladesh.  Int. J. Tourism Policy, 8(1), 42-64, 2018.

Haider, Z., Hossain, T., Siddiqui, O. Impact of Remittance on Consumption and Savings Behavior in Rural Areas of Bangladesh. Journal of Business, 01(04), 25-34, Sep 2016 

Siddiqui, O. Methods for Computing Missing Item Response in Psychometric Scale Construction.  American Journal of Biostatistics, 5 (1): 1.6, 2015

Siddiqui, O.  How Much Missing May Be Too Much in Clinical Trials of Neuropharmacological Drug Products.  Applied Clinical Research, Clinical Trials and Regulatory Affairs Journal, 1, 125-134, 2014 

Haider, Z.,  Dutta, C B., Siddiqui O.   Role of Bangladesh Small & Cottage Industries Corporation in Poverty Reduction. South Asia Economic Journal, 16(1), 103-121, 2015 

Siddiqui, O. MMRM Vs. MI in Dealing with Missing Data- A Comparison based on 25 NDA Data sets. Journal of Biopharmaceutical Statistics, 21(3), 423-436, 2011.

Siddiqui, O., Hershkowitz, N. Primary Efficacy Endpoint in Clinical Trials of Antiepileptic Drugs: Change or Percent Change, Drug Information Association,  44 (3), 343-350, 2010

Kordzakhia, G., Siddiqui, O, Huque, M. Method of balanced adjustment in testing coprimary endpoints. Statistics in Medicine, Vol. 29 (19): 2055–2066, 2010

Batarseh, L., Kleppinger, C., Mahjoob, K., Siddiqui, O. Clinical Trials in the Middle East and North Africa (MENA), International Analytical Paper Series, Office of International Programs, March 2012 

Siddiqui, O., Hung, J.H.M., O’Neill, R. Statistical Methods to Analyze Incomplete Clinical Trial  Data. Journal of Biopharmaceutical Statistics. 19(2), 227-246, 2009.

Siddiqui, O. Statistical Methods to Analyze Adverse Events Data of Randomized Clinical Trials. Journal of Biopharmaceutical Statistics. 19 (5), 889-899, 2009.

Bhattaram, A.V., Siddiqui, O., Kapcala, L.P., Gobburu, V.S.J. Endpoints and Analysis to Discern Disease Modifying Drug effects in early Parkinson’s disease. The AAPS Journal, 11 (3), 456-464, 2009

Hedeker D, Siddiqui O, Hu FB. Random-effects regression analysis of correlated grouped-time survival data.  Stat Methods Med Res. 2000 9(2):161-79.

Ali, M.W., Siddiqui, O.  Multiple imputation compared with some informative dropout procedures in the analysis of  longitudinal clinical data with dropouts.  Journal of Biopharmaceutical Statistics 2000 10(2):165-81.

Siddiqui, O., Ali, M.W.  Linear structural equation model in analyzing quality of life data  from clinical trials.  Journal of Biopharmaceutical Statistics 1999 9(4):165-81. 

Siddiqui, O., Ali, M.W.   A comparison of the random-effects pattern mixture model with last observation carried forward (LOCF) analysis in longitudinal clinical trials with  dropouts.  Journal of Biopharmaceutical Statistics 1998 8(4): 545-563.

Siddiqui, O, Mott, J, Anderson T, Flay, B.  The application of Poisson random-effects regression models to the analyses of adolescents’ current level of smoking.  Preventive Medicine 1999 29(2):92-101.

Siddiqui, O., Hedeker, D.,  Flay, B.R., and Hu, F. B.  Intraclass correlation estimates  in a school-based smoking  prevention study: Outcome and mediating variables by gender and  ethnicity.  American Journal of Epidemiology 1996, Vol. 144, N 4: 425-433. 

Siddiqui, O., Flay, B.R., and Hu, F.B.   Factors affecting attrition in a longitudinal smoking prevention study.  Preventive Medicine 1996 Vol. 25: 554-560. 

Siddiqui, O., Mott, J.A., Anderson, T.L, Flay, B.R.  Characteristics of inconsistent respondents who have ever used drugs in a school-based study.  Substance Use &  Misuse 1999, 34(2):269-295.

Hu, F. B., Hedeker, D., Flay, B.R, Sussman, S., Day, L.E, Siddiqui, O. The patterns and predictors of smokeless tobacco use among urban public school teenagers.  American  Journal of  Preventive Medicine 1996 12(1):22-8.

Hu, F. B., Day, L.E., Flay, B.R., Siddiqui, O., Sussman, S., & Richardson, J. The patterns of use of smokeless tobacco and the unidimensional model of drug involvement.  Additive  Behaviors 1997 22(2):257-61.

Flay, B.R., Miller, T.Q, Hedeker, D., Siddiqui, O., Brannon, B.R.  The television school and family smoking prevention and cessation project VIII. Student outcomes and mediating variables. Preventive Medicine 1995 24(1):29-40.

Hu, F.B., Hedeker, D., Flay, B.R, Siddiqui, O., Day, L.E. The influences of friends and parental smoking on adolescent smoking behavior: The effects of time and prior smoking.  Journal of Applied Social Psychology Vol. 25, N 22, 1995.

Flay, B.R., Hu, F. B., Siddiqui, O., Day, L.E., Hedeker, D., Petraistis, J., Richardson, J., and Sussman, S. Differential influence of parental smoking  and friends smoking  on adolescent initiation of smoking and  escalation of smoking.  Journal of  Health and Social Behavior Vol. 35 N 3, 1994.

Siddiqui, O.  Estimating the completeness of adult deaths from retrospective information.  Journal  of Statistical Studies  Vol. 1, 1981,  Bangladesh.

Presentation: 

Siddiqui, O. How Much Missing Data Are Too Much in Clinical Trials of Neuropharmacological Drug Products . Joint Statistical Meeting, San Diego, Jul 28- Aug 2, 2012 

Siddiqui, O. Statistical Method to Analyze Data from Delayed Start Design in Parkinson’s Disease. FDA/Industry Statistics Workshop, Virginia, Sept. 18-20, 2007 

Siddiqui, O. Application of Disease Model in Parkinson’s Disease.  DIA Meeting, Washington DC, Jan 24-25, 2007 

Siddiqui, O.  Statistical Method to Analyze Incomplete Clinical Trial Data.  Presented at Joint  Statistical Meetings, Washington, Seattle, August 2006.

Siddiqui, O., Hung, J.H.M. Statistical Method to Analyze Longitudinal Clinical Trial Incomplete data.  Presented at Joint Statistical Meetings, San Francisco, California, August 2003. 

Siddiqui, O. Methods for Imputing Missing Item Responses in Psychometric Scale Construction. Presented at Joint Statistical Meetings, New York, August 2002. 

Siddiqui, O.  Weibull random-effects regression models for clustered survival data with applications. Presented at  Joint Statistical Meetings, Anaheim, August 1997.

Siddiqui, O., Ali, M. W., Talukder, E.  A comparison of random-effects pattern mixture model with last observation carried forward (LOCF) analysis in longitudinal clinical trials with dropouts. Presented at Joint Statistical  Meetings, Anaheim, August 1997.

Siddiqui, O., Hedeker, D.  Poisson random-effects regression models for clustered count data with an application. Presented at Joint Statistical Meetings, Chicago, August 1996.

Hedeker, D., Siddiqui, O., Campbell R. T. & Flay, B. R.  Random-effects regression for discrete-time data. Presented at Biometric Society Eastern North Region 1996, Spring Meeting.

Received Research Grants (As a Principal Investigator) Received from CDER- Regulatory Science and Review Enhancement (RSR) Program

Year 2010

RSR number: RSR- 10-15

Title: Handling missing data of multi-treatment multi-period crossover clinical trials. (I am a Co-PI of the project).

Year 2007

RSR number: RSR- 07-50

Title: Statistical methods to analyze safety data of phase III clinical trials

Year 2006

RSR number: RSR -06-09

Title:  Appropriateness of the available statistical methods to analyze safety data from  Phase III clinical trials in drug development process

Year 2006

Title: Statistical analyses of gender-specific safety data from New Drug Application  submissions. Awarded by Office of Women Health (OWH) OWH Intramural Science Program

Year 2005

Project number: RSR-05-11

Title: Mixed Model Repeated Measures (MMRM) Approach Versus Pattern-Mixture Modeling approach in evaluating efficacy of    study drug development process.

Year 2004

RSR Number: RSR-04-13

Title: Mixed Model Repeated Measures approach versus Last Observation Carried Forward approach in evaluating efficacy of a study drug in drug development process.

Year 2003

RSR number: RSR-03-15.

Project Title: Mixed Model Repeated Measures (MMRM) approach versus Last Observation Carried Forward (LOCF) approach in evaluating efficacy of study drug in drug development process.

Year 2002

RSR number: RSR-02-15.

Project Title: Mixed Model Repeated Measures (MMRM) approach versus Last Observation Carried Forward (LOCF) approach in evaluating efficacy of study drug in drug development process.