In spite of having a concordant scientific base, biostatistics; and epidemiology may not always have harmony in their philosophical as well as operational stands. Part of this dissension is due to a less than full appreciation of each others basic foundation and objectives, and there is ample room for better interaction and coordination. Incorporation of 'local' factors (and covariates), in epidemiological modelling and statistical analysis is a vital component in this respect. With reference to some of the vital epidemiological issues in Bangladesh, the role of biostatistics in their effective resolution is discussed here in a broader perspective.